This gene encodes a protein that associates with the centromere-kinetochore complex.
The protein is a component of the nuclear matrix during the G2 phase of interphase.
In late G2 the protein associates with the kinetochore and maintains this association through early anaphase.
It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded.
The localization of this protein suggests that it may play a role in chromosome segregation during mitotis.
It is thought to form either a homodimer or heterodimer.
Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.
Applications:Suitable for use in ELISA, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000-1:5000Immunohistochemistry: 1:25-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
