84-4295-79　CACNA1A 100ul　308679

特徴

• Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression.
• Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits.
• The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity.
• The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S.
• This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue.
• Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2.
• This gene also exhibits polymorphic variation due to (CAG)n-repeats.
• Multiple transcript variants encoding different isoforms have been found for this gene.
• In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease.
• But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract.
• Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.
• Applications:Suitable for use in ELISA, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1000-1:2000Immunohistochemistry: 1:15-1:50Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.