84-4291-19　ADPRHL2 100ul　305072

特徴

• This gene encodes a member of the ADP-ribosylglycohydrolase family.
• The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins.
• This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.
• Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase.
• Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells.
• Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds.
• Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1000-1:2000Western Blot: 1:200-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.