This gene encodes a member of the runt domain-containing family of transcription factors.
A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription.
It also interacts with other transcription factors.
It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer.
Multiple transcript variants encoding different isoforms have been found for this gene.
[provided by RefSeq, Jul 2008]
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000-1:5000Western Blot: 1:200-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
; IHC: 1:25-1:100
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
Specificity：Recognizes human RUNX3. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide of human RUNX3
Shelf Life：1year
Swiss Prot Number：Q13761
EU Commodity Code：30021010
商品名：RUNX3 (Acute Myeloid Leukemia 2 Protein, Acute Myeloid Leukemia Gene 2, AML 2, AML2, CBF alpha 3, CBF-alpha-3, CBFA 3, CBFA3, Core Binding Factor alpha 3 Subunit, Core Binding Factor, Core Binding Factor Runt Domain alpha Subunit 3, Core Binding Factor Subunit alpha 3, Core-binding Factor, Core-binding Factor Subunit alpha-3, Oncogene AML 2, Oncogene AML-2, PEA2 alpha C, PEA2-alpha C, PEBP2 alpha C, PEBP2-alpha C, Pebp2a3, PEBP2aC, Polyomavirus Enhancer Binding Protein 2 alpha C Subunit, Polyomavirus Enhancer-binding Protein 2 alpha C Subunit, Runt Domain alpha Subunit 3, Runt Related Transcription Factor 3, Runt-related Transcription Factor 3, RUNX 3, Runx3, SL3 3 Enhancer Factor 1 alpha C Subunit, SL3-3 Enhancer Factor 1 alpha C Subunit, SL3/AKV Core Binding Factor alpha C Subunit, SL3/AKV Core-binding Factor alpha C Subunit, Transcription Factor AML2) 100ul
