BCAS3 (breast carcinoma amplified sequence 3), also designated MAAB or GAOB1, is a 913aa protein that is believed to be involved in breast cancer progression.
The gene is regulated by ER (estrogen receptor alpha) and expressed in multiple tissues, including malignant human brain lesions.
It is overexpressed and amplified in breast cancer cell lines.
BCAS3 contains three WD40 repeat regions, a bromodomain, a rare zinc-finger motif, four probable DNA-binding domains, and two kinase-inducible phosphorylation domains.
Five variants are produced due to alternative splicing.
BCAS3 interacts with histone H3 and PCAF, which is indicative of histone acetyltransferase activity.
BCAS3 also exhibits ER transactiviation activity by acting as a coactivator with PELP1 or MTA1.
The amplification and translocation between the BCAS3 gene and the BCAS4 gene results in a fusion transcript is overexpressed in MCF-7 cells.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:2000-1:5000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
Specificity：Recognizes human BCAS3. Species Crossreactivity: mouse
