84-4264-18　GJB6 100ul　317211

特徴

• Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells.
• They are formed by two hemichannels, made up of six connexin proteins assembled in groups.
• Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm.
• The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel.
• In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present.
• This gene encodes one of the connexin proteins.
• Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:ELISA: 1:1000-1:5000Western Blot: 1:1000-1:5000Immunohistochemistry (paraffin): 1:50-1:150Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.