ECRG4 (esophageal cancer-related gene 4 protein), also known as augurin or C2orf40, is a 148aa secreted protein.
Belonging to the augurin family, ECRG4 is thought to be a hormone.
It has also been suggested that ECRG4 may act as a tumor suppressor.
The gene that encodes ECRG4 maps to human chromosome 2, which consists of 237 million bases encoding over 1,400 genes, making up ~8% of the human genome.
A number of genetic diseases are linked to genes on chromosome 2.
Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene.
The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8.
An extremely rare recessive genetic disorder, Alstr m syndrome is due to mutations in the ALMS1 gene.
Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000-1:2000Immunohistochemistry: 1:25-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
