The predominant cause of spermatogenic arrest of meiosis is the failure of homologous chromosomes to accurately synapse.
MEI1 (Meiosis inhibitor protein 1), also designated Meiosis defective protein 1, is a 1274aa protein that is likely required for the formation of genetically programmed double-strand breaks, the first step in the initiation of meiosis.
With predominant expression in testis, it is likely that defects of the gene encoding MEI1 results in male infertility.
Interestingly, studies show that genetic variation in the MEI gene possibly predisposes European Americans but not Israeli men to infertility by meiotic arrest.
Human MEI1 shares 79% sequence similarity with its mouse homolog.
There are seven isoforms of MEI1 that are produced as a result of alternative splicing events.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000-1:2000Immunohistochemistry: 1:25-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
