FAM3B (family with sequence similarity 3, member B), also known as ORF9, C21orf11 or PANDER, is a 235aa secreted protein that localizes to discrete vesicular and perinuclear structures.
Expressed at high levels in pancreas and at lower levels in kidney, colon, testis, prostate and small intestine, FAM3B functions as an islet-specific cytokine that promotes apoptosis and may inhibit Insulin secretion from beta-cells, possibly playing a role in overall pancreatic activity.
Human FAM3B shares 78% sequence identity with its mouse counterpart, suggesting a conserved role between species.
Three isoforms of FAM3B, designated A, B and C, exist due to alternative splicing events.
The gene encoding FAM3B maps to human chromosome 21, which houses ~300 genes and comprises nearly 1.5% of the human genome.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:2000-1:5000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
