84-4230-71　DDIT4 50ul　313158

特徴

• REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS).
• REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases.
• As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin.
• In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level.
• REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP.
• It is crucial in the coupling of extra- and intracellular cues to FRAP regulation.
• The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness.
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1000-1:2000Immunohistochemistry: 1:25-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.