Synaptotagmin XVII (SytXVII), also known as Synaptotagmin-17 (SYT17) or Protein B/K, is a 474aa peripheral membrane protein that belongs to the Synaptotagmin family and contains two C2 domains.
While expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus, amygdala, substantia nigra and pituitary), kidney and prostate, Synaptotagmin XVII is also expressed in fetal brain, kidney and lung.
The gene that encodes Synaptotagmin XVII contains 100,082 bases and maps to human chromosome 16p12.3.
Encoding over 900 genes and consisting of ~90 million base pairs, chromosome 16 makes up nearly 3% of the human genome and is associated with a variety of genetic disorders, such as giant axonal neuropathy, Rubinstein-Taybi syndrome and Crohn's disease.
An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000-1:2000Western Blot: 1:200-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
Specificity：Species Crossreactivity: mouse and rat
