This gene encodes an aspartic proteinase that belongs to the peptidase family A1.
The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa.
This protein is also secreted into the serum.
This protein is synthesized as an inactive zymogen that includes a highly basic prosegment.
This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself.
Polymorphisms in this gene are associated with susceptibility to gastric cancers.
Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.
Alternate splicing results in multiple transcript variants.
A pseudogene of this gene is found on chromosome 1.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:2000-1:5000Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
