84-4204-16　PDCD4 (H731, Programmed cell death protein 4, Neoplastic transformation Inhibitor protein, Nuclear antigen H731-like, Protein 197/15a) 100ul　327701

特徴

• This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding.
• Alternative splicing results in multiple transcript variants.
• Inhibits translation initiation and cap-dependent translation.
• May excert its function by hindering the interaction between EIF4A1 and EIF4G.
• Inhibits the helicase activity of EIF4A.
• Modulates the activation of JUN kinase.
• Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription.
• May play a role in apoptosis.
• Tumor suppressor.
• Inhibits tumor promoter-induced neoplastic transformation.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1000-1:5000Western Blot: 1:200-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.