This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response.
This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways.
These pathways regulate that activation of numerous proinflammatory genes.
The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain.
Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections.
Alternate splicing results in multiple transcript variants.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000-1:5000Western Blot: 1:500-1:2000Immunohistochemistry: 1:25-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
Specificity：Species Crossreactivity: mouse and rat
