This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases.
This membrane-bound protein has a neuregulin binding domain but not an active kinase domain.
It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation.
However, it does form heterodimers with other EGF receptor family members which do have kinase activity.
Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.
Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors.
Alternate transcriptional splice variants encoding different isoforms have been characterized.
One isoform lacks the intermembrane region and is secreted outside the cell.
This form acts to modulate the activity of the membrane-bound form.
Additional splice variants have also been reported, but they have not been thoroughly characterized.
Applications:Suitable for use in ELISA, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000-1:5000Immunohistochemistry: 1:50-1:150Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
Specificity：Recognizes human ErbB3. Species Crossreactivity: mouse and rat
