TLE3, also named as KIAA1547 and ESG3, belongs to the WD repeat Groucho/TLE family.
It is a transcriptional corepressor that binds to a number of transcription factors.
It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling.
The effects of full-length TLE family members may be modulated by association with dominant-negative AES.
TLE3 is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorgenesis and classification of sarcomas.
It is a candidate biomarker of response to taxane therapy.
Applications:Suitable for use in ELISA, Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：150ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human TLE3. Species Crossreactivity: mouse and rat
