TDRKH (tudor and KH domain-containing protein), also known as TDRD2 (tudor domain-containing protein 2), is a 561aa protein that contains two KH domains and one tudor domain.
TDRKH exists as two alternatively spliced isoforms and interacts with HIWI and HILI2.
The gene that encodes TDRKH contains roughly 21,310 bases and maps to human chromosome 1q21.
With roughly 3,000 genes that span about 260 million base pairs, chromosome 1 makes up approximately 8% of the human genome.
There are also a large number of diseases associated with chromosome 1, notably, the rare aging disease Hutchinson-Gilford progeria which is associated with the LMNA gene that encodes lamin A.
When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs.
The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis.
Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.
Applications:Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：150ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human TDRKH. Species Crossreactivity: mouse and rat
