Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotin-amide and other pyridines.
NNMT activity in the human liver has a bimodal frequency distribution, indicating that its enzyme activity may be modulated through a genetic polymorphism, which could have functional implications for individual differences in drug and xenobiotic toxicity.
The gene that encodes human NNMT is ~16.5kb in length, consists of three exons and two introns and maps to 11q23.2.
NNMT isolated from the human liver was determined to be 969 nucleotides in length, with a 792 nucleotide open reading frame that encodes a 264aa protein.
The NNMT gene is presumed to be a significant genetic determinant of plasma homocysteine levels in Spanish families, since it encodes an enzyme involved in homocysteine synthesis.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：150ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human NNMT. Species Crossreactivity: mouse and rat
