Melanotransferrin is a member of the transferrin family of iron-binding proteins, which also includes serum transferrin, lactoferrin, and ovotransferrin, and it is highly expressed on melanoma cells.
Melanotransferrin, also designated p97, shares a high degree of homology with transferrin, but does not play a significant role in the uptake of iron.
Melanotransferrin utilizes a member of the low-density lipoprotein receptor family for transendothelial transport, which is not as efficient as the transport of transferrin through the corresponding transferrin receptor.
The gene encoding human melanotransferrin maps to chromosome 3q28-29, and is predominantly expressed as either a membrane bound protein or a secreted form of the protein.
Melanotransferrin is expressed in brain, where it may be involved in Alzheimer’s disease.
Melanotransferrin may also protect against membrane-lipid peroxidation, possess a metalloprotease activity, and possibly participate in intracellular adhesion.
Further research will be necessary to fully elucidate the functions of this protein.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human MFI2. Species Crossreactivity: mouse and rat
