The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development.
Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
FRZB is a Wnt-binding protein especially important in embryonic development.
It is a competitor for the cell-surface G-protein receptor Frizzled.
FRZB is localized in the extracellular plasma membrane.
Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors.
It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human FRZB. Species Crossreactivity: mouse and rat
