Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene.
It is mapped to 12p13.33.
The protein encoded by this gene is a member of the FOX family of transcription factors.
FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation.
FOXM1 gene is now known as a human proto-oncogene.
Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide.
It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion.
FOXM1 has been shown to modulate the epigenome.
It was found that overexpression of FOXM1 "brain washes" normal cells to adopt cancer-like epigenome.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human FOXM1. Species Crossreactivity: mouse and rat
