84-4054-22　CCL4 100ul　309568

特徴

• Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines.
• Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies.
• In C-C (or b) subfamily, the first two cysteines are adjacent.
• C-C chemokines are chemoattractants and activators for monocytes and T cells.
• C-C subfamily members include macrophage inflammatory protein (MIP)-1å,, MIP-1∫, MIP-2, MIP-3å,, MIP-3∫, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3.
• Research has shown that MIP-1∫ is more selective than MIP-1å,, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype.
• MIP-1å, is a more potent lymphocyte chemoattractant than MIP-1∫ and exhibits a broader range of chemoattractant specificities.
• It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF).
• MIP-1å, has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1∫ and RANTES.
• Recombinant human MIP-1å, acts as an inhibitor of different strains of HIV-1, HIV-2 and SIV infection in a dose-dependent manner.
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.