84-4052-86　IFNA1 100ul　319939

特徴

• Interferon-alpha1 is a member of the Type I IFN family best known for their antiviral activity.
• Most nucleated cells produce one or more Type I IFNs in response to viral infection.
• Secreted Type I IFN then induces viral protective responses in neighboring non-infected cells.
• Type I IFNs also enhance virus-induced apoptosis.
• Other IFN-alpha1 activities include enhancement of dendritic cell maturation and cytotoxic T cell activity.
• IFN-alpha1 binds to the IFN-alphaR1 and IFN-alphaR2 heterodimer.
• Intracellular signaling through the Jak/Stat pathway is best characterized.
• However, the PI3K, ERK, and p38 kinase pathways are also involved.
• The antiviral activities of the IFNs have led to their use in treating viral infections.
• Type I IFNs also appear to have an integral role in several autoimmune diseases.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.