Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome.
May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome.
Also positively regulates the activity of the minus-end directed microtubule motor protein dynein.
May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends.
Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome.
Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate.
Plays a role, together with DISC1, in the regulation of neurite outgrowth.
Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1.
Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Recombinant human Nuclear distribution protein nudE-like 1 protein (1-345aa)
