Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate.
Its function seems to be partially redundant with that of CNOT7.
Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation.
Additional complex functions may be a consequence of its influence on mRNA expression.
Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant human CCR4-NOT transcription complex subunit 8 protein (1-292aa)
