84-4046-37　Aminoacyl tRNA synthase complex-interacting multifunctional Protein 1 (AIMP1) 100ul　305831

特徴

• Non-catalytic component of the multisynthase complex.
• Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase.
• Binds tRNA.
• Possesses inflammatory cytokine activity.
• Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation.
• Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels.
• Promotes dermal fibroblast proliferation and wound repair.
• Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum.
• Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations.
• Induces maturation of dendritic cells and monocyte cell adhesion.
• Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-2000Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.