Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
Involved in cell mobility and transcription regulation through protein-protein interactions.
Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb.
Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP.
Inhibits G(o) alpha ATPase activity By similarity.
Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.
Involved in copper homeostasis/oxidative stress through copper ion reduction.
In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation.
Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV.
The splice isoforms that contain the BPTI domain possess protease inhibitor activity.
Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons.
Provides Cu2+ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, PH 7.4, 0.03% Proclin 300, 50% glycerol.
