84-4026-08　papillomavirus type 18 Minor capsid Protein L2 (L2) 50ug　327453

特徴

• Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.
• Plays a role in capsid stabilization through interaction with the major capsid protein L1.
• Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape.
• It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.
• Mediates the viral genome import into the nucleus through binding to host importins.
• Mediates the viral genome import into the nucleus through binding to host importins.
• Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection.
• Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.
• During virion assembly, encapsidates the genome by direct interaction with the viral DNA (By similarity).
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.