84-4011-21　［取扱停止］Meteorin-like Protein (HRP) 50ug　323748

特徴

• Hormone induced following exercise or cold exposure that promotes energy expenditure.
• Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation.
• Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance.
• Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions.
• Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat.
• Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.