G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin).
Has high affinity for CRH and UCN.
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase.
Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
Inhibits the activity of the calcium channel CACNA1H.
Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress.
Plays a role in the response to anxiogenic stimuli.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, PH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Biotin
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Recombinant human Corticotropin-releasing factor receptor 1 protein
