SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.
SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway.
Through binding to JAKs, inhibits their kinase activity.
In vitro, also suppresses Tec protein-tyrosine activity.
Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF).
Regulates interferon-gamma mediated sensory neuron survival By similarity.
Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Seems to recognize JAK2.
SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, PH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant human Suppressor of cytokine signaling 1 protein
