SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.
SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway.
Through binding to JAKs, inhibits their kinase activity.
In vitro, also suppresses Tec protein-tyrosine activity.
Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF).
Regulates interferon-gamma mediated sensory neuron survival By similarity.
Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Seems to recognize JAK2.
SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, PH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with horseradish peroxidase (HRP)
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant human Suppressor of cytokine signaling 1 protein
