Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
Involved in cell mobility and transcription regulation through protein-protein interactions.
Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb.
Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP.
Inhibits G(o) alpha ATPase activity By similarity.
Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.
Involved in copper homeostasis/oxidative stress through copper ion reduction.
In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation.
Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV.
The splice isoforms that contain the BPTI domain possess protease inhibitor activity.
Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons.
Ref.36 Ref.63 Ref.65 Ref.88 Ref.89 Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity.
Bind transient metals such as copper, zinc and iron.
In vitro, can reduce Cu2+ and Fe3+ to Cu+ and Fe2+, respectively.
Beta-amyloid 42 is a more effective reductant than beta-amyloid 40.
Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins.
Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses.
Promotes both tau aggregation and TPK II-mediated phosphorylation.
Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity.
Ref.36 Ref.63 Ref.65 Ref.88 Ref.89 Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain By similarity.
Ref.36 Ref.63 Ref.65 Ref.88 Ref.89 The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
Ref.36 Ref.63 Ref.65 Ref.88 Ref.89 N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, PH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human APP.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human Amyloid beta A4.
