Key component in the assembly and functioning of vertebrate striated muscles.
By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere.
The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle.
In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis.
Might link the lamina network to chromatin or nuclear actin, or both during interphase.
Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human Titin.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa5398-5604 of human Titin.
