C3 plays a central role in the activation of the complement system.
Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways.
After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
Ref.5 Ref.11 Ref.14 Ref.15 Ref.16 Ref.22 Ref.25 Ref.30 Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process.
It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Ref.5 Ref.11 Ref.14 Ref.15 Ref.16 Ref.22 Ref.25 Ref.30 Acylation stimulating protein (ASP): adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance.
Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways.
Ligand for GPR77.
Promotes the phosphorylation, ARRB2-mediated internalization and recycling of GPR77.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Biotin
