Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity.
Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification.
Also activated by low pH, citrate and phorbol esters.
Increase of intracellular Ca2+ potentiates currents.
Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.
Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers.
Acts as a regulator of intracellular Ca2+ in synoviocytes.
Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant human Transient receptor potential cation channel subfamily V member 4 protein (1-230aa)
