Mediates NK cell adhesion and triggers NK cell effector functions.
Binds two different NK cell receptors: CD96 and CD226.
These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell.
This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells.
May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell.
This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion.
Plays a role in mediating tumor cell invasion and migration.
Serves as a receptor for poliovirus attachment to target cells.
May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1.
This interaction would drive the virus-containing vesicle to the axonal retrograde transport.2 Publications
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant human Poliovirus receptor protein (220-345aa)
