84-3916-13　Peptidyl-prolyl cis-trans isomerase D (PPID) 100ul　327900

特徴

• PPIases accelerate the folding of proteins.
• It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
• Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes.
• Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control.
• May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes.
• May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus.
• May regulate MYB by inhibiting its DNA-binding activity.
• Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer, the function is independent of HSP90 but requires the chaperone activity.
• Involved in regulation of UV radiation-induced apoptosis.
• Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines.
• May be involved in hepatitis C virus (HCV) replication and release.
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-5000Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.