84-3915-76　NAD-dependent Protein deacetylase sirtuin-6 (SIRT6) 100ul　325152

特徴

• NAD-dependent protein deacetylase.
• Has deacetylase activity towards histone H3K9Ac and H3K56Ac.
• Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle.
• Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes.
• Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis.
• Required for genomic stability.
• Regulates the production of TNF protein.
• Has a role in the regulation of life span (By similarity).
• Deacetylation of nucleosomes interferes with RELA binding to target DNA.
• May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance.
• Required for genomic stability.
• Required for normal IGF1 serum levels and normal glucose homeostasis.
• Modulates cellular senescence and apoptosis.
• On DNA damage, promotes DNA end resection via deacetylation of RBBP8.
• Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.