84-3915-28　Baculoviral IAP repeat-containing Protein 7 (BIRC7) 100ul　307558

特徴

• Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control.
• Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity.
• As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival.
• May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions.
• Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine.
• Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2.
• This activation depends on TAB1 and NR2C2/TAK1.
• In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9.
• Isoform 1 blocks staurosporine-induced apoptosis.
• Isoform 2 blocks etoposide-induced apoptosis.
• Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:200-1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.