84-3913-72 TOPBP1 (DNA topoisomerase 2 Binding Protein 1, DNA topoisomerase 2-Binding Protein 1, DNA topoisomerase II Binding Protein, DNA topoisomerase II Binding Protein 1, DNA topoisomerase II-beta-Binding Protein 1, DNA topoisomerase II-Binding Protein 1, DNA topoisomerase IIbeta Binding Protein 1, Hypothetical Protein KIAA0259 [Fragment], KIAA0259, TOP2BP1, TOPB1_HUMAN, TOPBP 1, TOPBP1, Topoisomeras ... 337584
84-3913-72 TOPBP1 (DNA topoisomerase 2 Binding Protein 1, DNA topoisomerase 2-Binding Protein 1, DNA topoisomerase II Binding Protein, DNA topoisomerase II Binding Protein 1, DNA topoisomerase II-beta-Binding Protein 1, DNA topoisomerase II-Binding Protein 1, DNA topoisomerase IIbeta Binding Protein 1, Hypothetical Protein KIAA0259 [Fragment], KIAA0259, TOP2BP1, TOPB1_HUMAN, TOPBP 1, TOPBP1, Topoisomeras ... 337584
Plays a role in the rescue of stalled replication forks and checkpoint control.
Binds double-stranded DNA breaks and nicks as well as single-stranded DNA.
Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters.
Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage.
Induces a large increase in the kinase activity of ATR.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant human DNA topoisomerase 2-binding protein 1 protein (aa1253-1522)
Shelf Life：1year
Swiss Prot Number：Q92547
EU Commodity Code：30021010
商品名：TOPBP1 (DNA topoisomerase 2 Binding Protein 1, DNA topoisomerase 2-Binding Protein 1, DNA topoisomerase II Binding Protein, DNA topoisomerase II Binding Protein 1, DNA topoisomerase II-beta-Binding Protein 1, DNA topoisomerase II-Binding Protein 1, DNA topoisomerase IIbeta Binding Protein 1, Hypothetical Protein KIAA0259 [Fragment], KIAA0259, TOP2BP1, TOPB1_HUMAN, TOPBP 1, TOPBP1, Topoisomerase (DNA) II Binding Protein 1, Topoisomerase II Binding Protein 1) 100ul
![TOPBP1 (DNA topoisomerase 2 Binding Protein 1, DNA topoisomerase 2-Binding Protein 1, DNA topoisomerase II Binding Protein, DNA topoisomerase II Binding Protein 1, DNA topoisomerase II-beta-Binding Protein 1, DNA topoisomerase II-Binding Protein 1, DNA topoisomerase IIbeta Binding Protein 1, Hypothetical Protein KIAA0259 [Fragment], KIAA0259, TOP2BP1, TOPB1_HUMAN, TOPBP 1, TOPBP1, Topoisomeras ...](https://aimg.as-1.co.jp/c/84/3913/72/85133520.jpg)