G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances.
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.
Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.
Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores.
Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity.
May play a role in the perception of pain.
Plays a role in the regulation of behavior, including impulsive behavior.
Required for normal proliferation of embryonic cardiac myocytes and normal heart development.
Protects cardiomyocytes against apoptosis.
Plays a role in the adaptation of pulmonary arteries to chronic hypoxia.
Plays a role in vasoconstriction.
Required for normal osteoblast function and proliferation, and for maintaining normal bone density.
Required for normal proliferation of the interstitial cells of Cajal in the intestine.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant human 5-hydroxytryptamine receptor 2B protein (382-481aa)
