Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors.
Does not seem to be essential for HBV infection.
May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).
Most of cytosolic activities involve modulation of cytosolic calcium.
The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.
By binding to human DDB1, may affect cell viability and stimulate genome replication.
May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.
May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC).
Moderately stimulates transcription of many different viral and cellular transcription elements.
Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
May bind bZIP transcription factors like CREB1 (By similarity).
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Biotin
Specificity：Hepatitis B virus genotype D
Isotype：IgG
Calc Applications Abbrev：E
Immunogen：Recombinant Hepatitis B virus genotype D Protein X protein
