84-3884-60　DAPK2 (Biotin) 50ug　313050

特徴

• Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy.
• Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting.
• The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles.
• Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells.
• May play a role in granulocytic maturation.
• Isoform 2 is not regulated by calmodulin.
• It can phosphorylate MYL9.
• It can induce membrane blebbing and autophagic cell death.
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.