Palladin, also known as PALLD, PNCA1 or SIH002, is a 1383aa protein that localizes to both the cytoplasm and the cytoskeleton and contains five immunoglobulin (Ig)-like domains.
Expressed as several alternatively spliced isoforms that are found in kidney, prostate, ovary and colon, palladin functions as a cytoskeletal protein that is required both for the organization of the Actin cytoskeleton, as well as for the establishment of proper cell motility, cell adhesion and cell-matrix interactions.
Palladin interacts with Eps8, LASP-1 and VASP and may also play a role in cytoskeletal scaffolding and Actin remodeling.
In response to DNA damage, palladin is subject to phosphorylation on select serine residues.
Defects in the gene encoding palladin may increase genetic susceptibility to pancreatic cancer, strongly suggesting a role for palladin in tumorigenesis.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:20,000Immunohistochemistry: 1:100-1:300Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human PALLD. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to the Internal region of human Palladin.
