Centrosomes are the major microtubule-organizing centers of mammalian cells.
They are composed of a centriole pair and surrounding microtubule-nucleating material termed pericentriolar material (PCM).
Bipolar mitotic spindle assembly relies on two intertwined processes: centriole duplication and centrosome maturation.
Failure to properly orchestrate centrosome duplication and maturation is subsequently linked to spindle defects, which can result in aneuploidy and promote cancer progression.
The CEP41 (centrosomal protein of 41kD) gene encodes a protein of 373aa that is alternatively spliced into 4 isoforms.
Isoforms 1 and 4 are expressed in testis, as well as in and fetal brain and liver.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:40,000Immunohistochemistry: 1:100-1:300Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human CEP41.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the Internal region of human CEP41.
