Brain-specific angiogenesis inhibitors, including BAI-1, BAI-2, and BAI-3, are integral membrane proteins belonging to the G-protein coupled receptor 2 family.
In addition to inhibiting angiogenesis in the brain, BAI proteins are also expressed in the heart, thymus, skeletal muscle, and a variety of cell lines.
BAI-3 is predominantly expressed in brain.
Reduced expression may be observed in some glioblastoma cell lines suggesting that BAI-3 may function in the suppression of glioblastoma.
Localization of BAI-3 in most neurons of the cerebral cortex is analogous with BAI-1 and BAI-2 expression in the adult brain, but varies in the developing brain.
The activity of brain-specific angiogenesis inhibitor proteins has been inversely correlated with vascularization in some cancer tissues.
BAI-3 activity may be significant in the early phases of ishemia-induced brain angiogenesis and in brain tumor progression.
A better understanding of the anti-angiogenic activity of these BAIs may offer potential therapeutic benefits.
Applications:Suitable for use in Immunofluorescence, ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:200-1:1000ELISA: 1:10,000Immunohistochemistry: 1:100-1:300Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human BAI3. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E IF IHC
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to the N-terminal region of human BAI-3.
