STEAP2 (six transmembrane epithelial antigen of the prostate 2), also known as STMP, IPCA1, PUMPCn, STAMP1 or PCANAP1, is a 490aa multi-pass membrane protein that localizes to the cell membrane and the endosomal membrane, as well as to the Golgi and to vesicular tubular structures in the cytosol.
Highly expressed in prostate and present at lower levels in kidney, heart, ovary, brain and pancreas, STEAP2 contains one ferric oxidoreductase domain and, using FAD as a cofactor, functions as a metalloreductase that is able to reduce both Cu(2+) and Fe(3+) to Cu(1+) and Fe(2+), respectively, thereby playing a role in iron and copper metabolism.
Overexpression of STEAP2 is associated with the progression of prostate cancer, suggesting a role for STEAP2 in tumorigenesis.
Multiple isoforms of STEAP2 exist due to alternative splicing events.
Applications:Suitable for use in Immunofluorescence, ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:200-1:1000ELISA: 1:10,000Immunohistochemistry: 1:100-1:300Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human STEAP2. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E IF IHC
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to the C-terminal region of human STEAP2.
