The Latrophilin family of G protein-coupled receptors consists of three members, latrophilin-1, 2 and 3, each of which displays distinct tissue distribution and function.
Latrophilin-1, the most characterized member of this family, acts as a receptor for a-latrotoxin, a component of venom from the black widow spider.
Binding of a-latrotoxin to latrophilin-1 triggers synaptic vesicle exocytosis via both Ca2+-dependent and -independent mechanisms, resulting in vesicle depletion.
Latrophilin-1 is abundant in brain and present in endocrine cells.
Latrophilin-3 is also brain-specific, whereas latrophilin-2 expression is ubiquitous.
Applications:Suitable for use in Immunofluorescence and ELISA.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:200-1:1000ELISA: 1:5000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human LPHN1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IF
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to the Internal region of human Latrophilin-1.
