Alpha1D-adrenergicreceptors(alpha1D-ARs)couple to Gq/11 and participate directly in sympathetic regulation of systemic blood pressure by vasoconstriction.
alpha1D-AR can form hetero-oligomers with alpha1B receptors.
alpha1D-AR transcripts are abundant in prostate and aorta.
alpha1A adrenergic receptors(alpha1A-ARs) mediate actionsin the sympathetic nervoussystem through the binding of the catecholamines, epinephrine and norepinephrine.
alpha1A-adrenergic receptors couple to Gq/11 and regulate blood pressure due to changesin vascular tone and cardiac output.
Alternative splicing of this gene generatesfour isoforms with distinct C-termini, and the different expression profile of these subtypes produces distinct patterns of activation.
alpha1A-AR transcripts are abundant in heart, brain, liver, and prostate.
alpha1A-AR transcriptsizes of 6.0, 4.0, 3.0, and 2.0kb have been detected in liver.
alpha1A-AR transcriptsizes of 6.0, 4.0 and 3.0 kb transcripts have been detected in heart, and 6.0kb and 4.0kb transcripts have been detected in prostate.
Applications:Suitable for use in Immunofluorescence, ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:200-1:1000ELISA: 1:20,000Immunohistochemistry: 1:100-1:300Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human ADRA1D.
Isotype：IgG
Calc Applications Abbrev：E IF IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the C-terminal region of human AR-alpha1D.
